Assistant Professor of Biological Science and Chemistry
Ph.D., Indian Institute of Science
Kalyan Chakrabarti has research interests in the interface between biology and chemistry. He held researcher positions in the Max Planck Institute for Biophysical Chemistry (Göttingen, Germany), the National Cancer Institute (in the National Institute of Health, USA) and the Howard Hughes Medical Institute in the Brandeis University, USA.
His work primarily focuses on protein dynamics and he is the coordinator of an international collaboration to develop a comprehensive framework for investigating protein dynamics involving the Max Planck Institutes in Göttingen and Potsdam, FreieUniversität, Berlin in Germany, and the University of Louisville, USA.
He obtained his B.Sc. Chemistry (Hons.) degree from the Presidency University, Kolkata. He went on to receive his master’s and doctorate degrees from the Indian Institute of Science, in biophysics with specialisation in Nuclear Magnetic Resonance spectroscopy of proteins. He has several contributions in the area of functional role of protein dynamics. In 2016, he along with an international collaboration published one of the most comprehensive examples of conformational selection in protein-protein interaction.
Chakrabarti et al.,High-power 1H composite pulse decoupling provides artifact free exchange-mediated saturation transfer (EST) experiments,Journal of Magnetic Resonance (2016) 269: 65-69. (from the Max Planck Institute).
Chakrabarti et al.,Conformational dynamics and allostery in E2:E3 interactions drive ubiquitination: gp78 and Ube2g2,Structure (2017) 25:794-805. (from the National Cancer Institute)
Chakrabarti et al., Conformational selection in a protein-protein interaction by dynamic pathway analysis,Cell Reports (2016) 14: 32-42. (from the HHMI/Brandeis Univ.).
Chakrabarti et al.,X-ray crystallographic and NMR studies of pantothenatesynthetase provide insights into the mechanism of homotropic inhibition by pantoate,FEBS Journal (2010) 277: 697-712. (from the Indian Institute of Science).