{"id":30349,"date":"2023-04-24T17:12:25","date_gmt":"2023-04-24T17:12:25","guid":{"rendered":"https:\/\/krea.edu.in\/sias\/?page_id=30349"},"modified":"2024-12-13T09:50:20","modified_gmt":"2024-12-13T09:50:20","slug":"dr-lakshman-varanasi","status":"publish","type":"page","link":"https:\/\/krea.edu.in\/sias\/dr-lakshman-varanasi\/","title":{"rendered":"Dr Lakshman Varanasi"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"30349\" class=\"elementor elementor-30349\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-cac80f7 elementor-section-full_width elementor-section-height-min-height elementor-section-height-default elementor-section-items-middle\" data-id=\"cac80f7\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-db23864\" data-id=\"db23864\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-455fe6a elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"455fe6a\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-9643c5b awsmgrid1\" data-id=\"9643c5b\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-430946f elementor-widget elementor-widget-image\" data-id=\"430946f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"500\" height=\"500\" src=\"https:\/\/www-cdn.krea.edu.in\/sias\/2023\/07\/Lakshman.png\" class=\"attachment-large size-large wp-image-30620\" alt=\"\" srcset=\"https:\/\/www-cdn.krea.edu.in\/sias\/2023\/07\/Lakshman.png 500w, https:\/\/www-cdn.krea.edu.in\/sias\/2023\/07\/Lakshman-300x300.png 300w, https:\/\/www-cdn.krea.edu.in\/sias\/2023\/07\/Lakshman-150x150.png 150w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-7571941 awsmgrid2\" data-id=\"7571941\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c0d6a8d elementor-widget elementor-widget-heading\" data-id=\"c0d6a8d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Dr Lakshman Varanasi<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c2bc406 elementor-widget elementor-widget-heading\" data-id=\"c2bc406\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Assistant Professor, Biological Sciences <\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-083b8c0 elementor-widget elementor-widget-heading\" data-id=\"083b8c0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Discipline Coordinator for Biological Sciences<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4c0c8e8 elementor-widget elementor-widget-heading\" data-id=\"4c0c8e8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Media Lab In-charge<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b2b93be elementor-widget elementor-widget-heading\" data-id=\"b2b93be\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">PhD, University of Mississippi Medical Center (UMMC)<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c994609 elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"c994609\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-envelope\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">lakshman.varanasi@krea.edu.in <\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-58d6189 e-grid-align-left elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-mobile elementor-shape-rounded elementor-grid-0 elementor-widget elementor-widget-social-icons\" data-id=\"58d6189\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"social-icons.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-social-icons-wrapper elementor-grid\" role=\"list\">\n\t\t\t\t\t\t\t<span class=\"elementor-grid-item\" 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class=\"elementor-screen-only\">Youtube<\/span>\n\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fab fa-youtube\"><\/i>\t\t\t\t\t<\/a>\n\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<span class=\"elementor-grid-item\" role=\"listitem\">\n\t\t\t\t\t<a class=\"elementor-icon elementor-social-icon elementor-social-icon-linkedin elementor-repeater-item-90a7b4d\" href=\"https:\/\/www.linkedin.com\/in\/lakshman-varanasi-58407910\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-screen-only\">Linkedin<\/span>\n\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fab fa-linkedin\"><\/i>\t\t\t\t\t<\/a>\n\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<span class=\"elementor-grid-item\" role=\"listitem\">\n\t\t\t\t\t<a class=\"elementor-icon elementor-social-icon elementor-social-icon-instagram elementor-repeater-item-69fc2d4\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-screen-only\">Instagram<\/span>\n\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fab 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class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-9282458\" data-id=\"9282458\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-798e5ce\" data-id=\"798e5ce\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4a566a2 elementor-tabs-view-horizontal elementor-widget elementor-widget-tabs\" data-id=\"4a566a2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"tabs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-tabs\">\n\t\t\t<div class=\"elementor-tabs-wrapper\" role=\"tablist\" >\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-7791\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"elementor-tab-content-7791\" aria-expanded=\"false\">About<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-7792\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-7792\" aria-expanded=\"false\">Research<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-7793\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-7793\" aria-expanded=\"false\">Publications<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-7794\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"4\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-7794\" aria-expanded=\"false\">Teaching Modules<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<div class=\"elementor-tabs-content-wrapper\" role=\"tablist\" aria-orientation=\"vertical\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"elementor-tab-content-7791\" aria-expanded=\"false\">About<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-7791\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-7791\" tabindex=\"0\" hidden=\"false\"><p>Dr Lakshman Varanasi is deeply invested in research in the detection and management of catastrophic lifestyle diseases such as cancer. His work has included basic and translational cancer research, and has centred on the early diagnosis of gastrointestinal cancers. Over the course of this work, his interests have evolved to include the gamut of disciplines that constitute precision medicine.<br \/><br \/>He is also engaged with industry to provide scientific expertise and depth for the development of biomedical systems, for the delivery and management of healthcare, such as in the use of electronic health information in prediction\/ diagnosis (Healthkon). Most recently, he has helped communicate stem-cell research, services, and products to the general public (Transcell Oncologics).<br \/><br \/>Dr Varanasi holds an undergraduate degree in Biochemistry and Microbiology from Osmania University (2002), Master\u2019s in Life Sciences from Jawaharlal Nehru University (2004) and a PhD in Biochemistry from the University of Mississippi Medical Center, Jackson, MS, USA (2010), where he worked on the mutational analysis of respiratory proteins in the bacterial model. Subsequently, he conducted post-doctoral research in Dr Luis Martinez\u2019s lab at UMMC, on the basic biology of DNA damage and repair in cancer cells. The work was a prelude to his work on cancer; his interest in protein analysis led him to studies on chemically modified proteins in the blood, as evidence for the presence of cancers of the gut, at the Institute of Molecular and Translational Medicine, Olomouc, in the Czech Republic.<br \/><br \/><\/p><p>His interest in health extends into his life in the workplace and outside it, and he is interested in writing, photography, yoga, and cycling.<\/p><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-7792\" aria-expanded=\"false\">Research<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-7792\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-7792\" tabindex=\"0\" hidden=\"hidden\"><p>Dr Varanasi\u2019s research so far has focused on the study of DNA damage and repair in cancer cells (Phi et al, 2012, Cell Cycle), and more recently, on the identification and use of certain proteins in the bloodstream for the purpose of identification of cancers of the gastrointestinal tract. These proteins are called biomarkers, and can enable the early diagnosis of certain cancers during a screening process. He has mentored doctoral, and bachelor\u2019s level students in the work involved in these projects.<\/p><p>Dr Varanasi\u2019s work has led to his interest in human health, and he continues this interest into his work at Krea. His work research centres around the influence of diet, lifestyle, and environment on the gut and respiratory microbiome and indirectly on human health. The microbiome is a collective of all the microbes that reside in a \u201cniche\u201d in the human body; the microbiomes of the body together have more microbes than the body has cells. They microbes subsist on nutrients that the host supplies, and appear to affect human health in myriad ways. Specifically, Dr Varanasi\u2019s work will involve the investigation of the microbiome\u2019s secretions into the human system and their physiological effect, and of how an imbalance in the microbial constituents causes dysbiosis and disease.<\/p><p>The larger questions that Dr Varanasi is interested in, and will try to address through his work at Krea, are these: What is the association between a person\u2019s physical and mental health and the microbiome\u2019s profile and chemicals it secretes? Is the microbiome of the gut an accurate index of an individual\u2019s health? Can the chemicals secreted be collectively considered a reliable surrogate for a healthy, or dysbiotic, microbiome?<\/p><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-7793\" aria-expanded=\"false\">Publications<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-7793\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-7793\" tabindex=\"0\" hidden=\"hidden\">1. Hruska M., Agrawal K., Holub D., Vaclavkova J., Vojta P., Varanasi L., Maceckova Z., Voller J., Dzubak P., Hajduch M. Deep probabilistic search detects protein variants in shotgun proteomics data independently of DNA\/RNA sequencing. Submitted to eLife [ID 14-10-2019-ISTR-eLife-52736]<br><br>2. Ozdian T, Holub D, Maceckova Z, Varanasi L, Rylova G, Rehulka J, Vaclavkova J, Slavik H, Moudry P, Znojek P, Stankova J, de Sanctis J B, Hajduch M, Dzubak P. Proteomic profiling reveals DNA damage, nucleolar and ribosomal stress are the main responses to oxaliplatin treatment in cancer cells. 2017 Journal of Proteomics 162, 73-85<br><br>3. Koudelakova V, Trojanec R, Vrbkova J, Donevska S, Bouchalova K, Kolar Z, Varanasi L, Hajduch M. Frequency of chromosome 17 polysomy in relation to CEP17 copy number in a large breast cancer cohort. Genes Chromosomes Cancer 2016, doi: 10.1002\/gcc.22337<br><br>4. Schadich E, Hlavac J, Volna T, Varanasi L, Hajduch M, Dzubak P. Effects of ginger phenylpropanoids and Quercetin on Nrf2-ARE pathway in human BJ fibroblasts and HaCaT Keratinocytes. Bio Med Res Int 2015, doi: 10.1155\/2016\/2173275<\/span><span lang=\"EN-US\" style=\"font-size: 12.0pt;\">\u00a0<br><br>5. Subramanian M, Francis P, Bilke S, Li XL, Hara T, Lu X, Jones MF, Walker RL, Zhu Y, Pineda M, Lee C, Varanasi L, Yang Y, Martinez LA, Luo J, Ambs S, Sharma S, Wakefield LM, Meltzer PS, Lal A. A mutant p53\/let-7i-axis-regulated gene network drives cell-migration, invasion and metastasis. Oncogene 2015, 34(9):1094- 104<br><br>6. Rylova G, Ozdian T, Varanasi L*, Soural M, Hlavac J, Holub D, Dzubak P, Hajduch M. Affinity-based methods in drug-target discovery. Current Drug Targets 2015, 16(1): 60- 76<br><br>7. Do PM, Varanasi L, Fan S, Li C, Kubacka I, Newman V, Chauhan K, Daniels SR, Boccetta M, Garrett MR, Li R, Martinez LA. Mutant p53 cooperates with ETS2 to promote etoposide resistance. Genes and Development 2012, 26(8): 830- 45<br><br>8. Varanasi L*, Do PM, Goluszko E, Martinez LA. Rad18 is a transcriptional target of E2F3. Cell Cycle 2012, 11(6): 1131- 41<br><br>9. Varanasi L*, Hosler JP. Subunit III-depleted cytochrome c oxidase provides insight into the process of proton-uptake by proteins. Biochimica Biophysica Acta, 2011<br><br>10. Varanasi L*, Hosler J. Alternative initial proton acceptors for the D-pathway of Rhodobacter sphaeroides cytochrome c oxidase. Biochemistry 2011, 50(14): 2820- 8<br><br>11. Varanasi L*, Mills D, Murphree A, Gray J, Purser C, Baker R, Hosler J. Altering conserved binding sites in cytochrome c oxidase of Rhodobacter sphaeroides perturbs the interaction between subunits I and III and promotes suicide inactivation of the enzyme. Biochemistry 2006, 45(50): 14896 \u2013 907<br><br>* First author publications\n<strong>Media\/News articles<\/strong>\n\nFormulating Haematopoietic Stem Cell Transplantation for Practitioners A technology-based health service: <a href=\"https:\/\/issuu.com\/verticaltalk\/docs\/pfa-issue41\/s\/11431004\">https:\/\/issuu.com\/verticaltalk\/docs\/pfa-issue41\/s\/11431004<\/a><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"4\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-7794\" aria-expanded=\"false\">Teaching Modules<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-7794\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"4\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-7794\" tabindex=\"0\" hidden=\"hidden\"><\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Dr Lakshman Varanasi Assistant Professor, Biological Sciences Discipline Coordinator for Biological Sciences Media Lab In-charge PhD, University of Mississippi Medical Center (UMMC) lakshman.varanasi@krea.edu.in Facebook Twitter Youtube Linkedin Instagram Link About Research Publications Teaching Modules About Dr Lakshman Varanasi is deeply invested in research in the detection and management of catastrophic lifestyle diseases such as cancer. &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/krea.edu.in\/sias\/dr-lakshman-varanasi\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Dr Lakshman Varanasi&#8221;<\/span><\/a><\/p>\n","protected":false},"author":10,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-30349","page","type-page","status-publish","hentry","entry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.3 (Yoast SEO v27.3) - 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