Dr Kalyan S Chakrabarti, Associate Dean (Students) and Associate Professor of Biological Sciences and Chemistry, SIAS, Krea University has co-authored an article titled Bifurcations in coupled amyloid-β aggregation-inflammation systems, published in the journal NPJ Systems Biology and Applications. The article was co-authored with Davood Bakhtiari (Stadtapotheke Calw Pharmacy) and Dr Nasrollah Rezaei-Ghaleh (University of Düsseldorf).
Dr Chakrabarti extends his gratitude to Krea University for providing computational facilities and intramural funding. He also acknowledges the contributions of Krea alumni Lipi Savitha, Kathan Pandya, Meghna Rao, Yazhini LA and Gauri Velloor, as well as SIAS student Netra Krishna, who have contributed to different aspects of the project as part of their Capstone Theses at Krea University. Additionally, he thanks Dr Abuthahir Abdul Rahuman and Professor Gaurav Raina for their discussions, which significantly contributed to the project’s conception.
About the Paper
In this article, the authors investigate a simple coupled system of amyloid-beta (Ab) aggregation and inflammation relevant in Alzheimer disease (AD) and demonstrate its complex and rich dynamics ranging from overdamped kinetics to sustained oscillations in dependence of various aggregation- and neuroinflammation-related parameters. They suggest that sustained oscillations in inflammatory response to Ab aggregation and its resultant exhaustion of the immune system can lead to a transition to a more progressive phase of amyloid pathology in AD brains. Accordingly, oscillations in aggregation and/or inflammation levels can serve as potential biomarkers in early diagnosis of AD. The authors also propose that the relative ease of triggering oscillatory dynamics in coupled aggregation-neuroinflammation systems should be taken into consideration in clinical trials related to anti-AD drug development.
Read the article here.
